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Cell Biology JoVE (Open Access) Citable · DOI

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

DOI: 10.3791/53569-v
What you'll learn
  • ✓ Administer neonatal motor tests to mice
  • ✓ Identify motor deficits in cerebral palsy model
  • ✓ Standardize motor testing for comparison
  • ✓ Apply battery to varied neonatal disorders
Protocol

Biopharma Insights Presented is a concise battery of mouse neonatal motor tests. Using these tests, neonatal motor deficits can be demonstrated in a variety of neonatal motor disorders. By having a standardized set of tests, results from different studies can be compared, allowing for better and accurate reporting between groups.

Difficulty
intermediate
Total time
~1-2 hours per litter (includes handling and testing)
Model organism
Neonatal mouse (e.g., C57BL/6)
Biosafety
BSL-1

Steps

1
Perform neonatal motor tests

Conduct a series of standardized motor tests on neonatal mice to assess motor function.

▶ 01:02
2
Analyze representative motor deficits

Evaluate motor performance at a single time-point in a cerebral palsy mouse model to observe deficits.

▶ 08:04
3
Review conclusions and comparisons

Summarize the utility of the motor test battery for comparing results across studies.

▶ 09:09
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