We demonstrate the semi-automated radiochemical synthesis of [18F]3F4AP and quality control procedures.
Assemble the semi-automated radiochemical synthesis apparatus and prepare all required reagents and solvents according to protocol specifications.
Load fluorine-18 precursor and execute the automated synthesis sequence, including nucleophilic fluorination and subsequent purification steps.
Conduct radiochemical purity assessment, specific activity determination, and sterility/endotoxin testing using HPLC and other standard QC methods.
Analyze QC results to determine radiochemical yield, molar activity, and overall product quality for clinical or research use.
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