Home › Cell Biology › Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
Cell Biology JoVE (Open Access) Citable · DOI

Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System

DOI: 10.3791/52554-v
What you'll learn
  • ✓ Implant wireless EEG transmitters in neonatal rodent models
  • ✓ Perform continuous telemetric EEG recordings without tethering
  • ✓ Troubleshoot transmitter placement and signal optimization
  • ✓ Analyze behavioral data concurrent with neural activity
Protocol

Biopharma Insights Here we demonstrate the use of a wireless enabling technology for electroencephalogram (EEG) in neonatal rodent models of human disease. With telemetry, there are no encumbering connections, thus allowing natural behaviors.

Difficulty
advanced
Total time
~2–3 hours per animal (surgery + recovery); continuous monitoring over days to weeks
Model organism
Neonatal rodent (rat/mouse) disease models
Biosafety
BSL-1

Steps

1
Prepare surgical site and anesthesia

Set up sterile surgical field and anesthetize neonatal rodent according to institutional protocol. Ensure proper positioning for head access.

▶ 01:49
2
Implant wireless EEG transmitter subcutaneously

Create incisions over skull for electrode placement, secure transmitter leads to cortical surface, and implant transmitter body subcutaneously. Ensure proper electrode positioning for signal quality.

▶ 03:16
3
Acquire continuous telemetric EEG recordings

Activate wireless receiver, verify signal quality, and begin data acquisition. Allow animal to recover and resume natural behaviors during monitoring.

▶ 06:18
4
Review transmitter design and technical specifications

Examine wireless system components, transmission range, battery life, and data storage capacity to optimize experimental design and troubleshoot signal issues.

▶ 07:30
💬 Comments coming soon