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Analytical Chem JoVE (Open Access) Citable · DOI

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

DOI: 10.3791/3439-v
What you'll learn
  • ✓ Perform axonal excitability testing to detect chemotherapy-induced neurotoxicity
  • ✓ Interpret excitability waveforms and identify pathophysiological patterns
  • ✓ Assess nerve function changes earlier than conventional clinical methods
Protocol

This abstract describes a novel method to assess the development of neurotoxicity in patients receiving chemotherapy treatment. While conventional assessment methods are limited in their ability to detect early changes in nerve function, nerve excitability techniques provide early identification of patients at risk of severe neurotoxicity and insight into pathophysiology.

Difficulty
advanced
Total time
~45 minutes per patient assessment

Steps

1
Prepare patient and axonal excitability equipment

Position patient and calibrate axonal excitability apparatus according to protocol standards. Ensure electrode placement and recording equipment are properly configured for measurement.

▶ 01:32
2
Execute axonal excitability test protocols

Apply standardized excitability stimulation protocols to assess nerve response characteristics. Collect data on strength-duration properties and other excitability parameters.

▶ 03:46
3
Analyze excitability data and interpret results

Process recorded excitability waveforms and compare against normal reference values. Identify abnormal patterns indicative of neurotoxicity development.

▶ 05:43
4
Review excitability result examples and patterns

Examine representative excitability traces from affected versus unaffected patients. Recognize diagnostic signatures of chemotherapy-induced axonal damage.

▶ 06:57
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