Home › Biochemistry › Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
Biochemistry JoVE (Open Access) Citable · DOI

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

DOI: 10.3791/54746-v
What you'll learn
  • ✓ Perform foramen ovale electrode implantation for intracranial epilepsy monitoring
  • ✓ Conduct network analysis on mesial temporal lobe recordings
  • ✓ Interpret network imbalance patterns during seizure activity
Protocol

This protocol describes a procedure to track the evolution of mesial network measures in temporal lobe epilepsy (TLE) patients. It is based on the combination of intracranial recordings with a novel numerical technique for data analysis. Specifically, we present a protocol for network analyses of foramen ovale recordings.

Difficulty
advanced
Total time
~2–4 hours per patient (implantation); ongoing monitoring and analysis per recording session

Steps

1
Implant foramen ovale electrodes in patient

Surgical placement of foramen ovale electrodes for intracranial recording of mesial temporal lobe activity. This procedure enables direct capture of neuronal signals from drug-resistant epilepsy patients.

▶ 01:18
2
Acquire foramen ovale electrode recordings

Record intracranial electrophysiological data from implanted foramen ovale electrodes during baseline and ictal periods. Data acquisition provides the raw signal necessary for subsequent network analysis.

▶ 04:02
3
Analyze network measures from electrode data

Apply numerical techniques to quantify mesial network evolution and detect network imbalance signatures during seizures. Results demonstrate how network analysis can identify pathological connectivity patterns in temporal lobe epilepsy.

▶ 06:02
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