Home › Neuroscience › The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Neuroscience JoVE (Open Access) Citable · DOI

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

DOI: 10.3791/58937-v
What you'll learn
  • ✓ Apply TTFields transducer arrays correctly on glioblastoma patients
  • ✓ Assemble and operate TTFields device system for treatment delivery
  • ✓ Plan tumor treatment positioning using imaging and localization
  • ✓ Exchange and maintain transducer arrays during ongoing therapy
Protocol

Biopharma Insights Glioblastoma is the most common and aggressive primary brain malignancy in adults, with most tumors recurring after initial treatment. Tumor Treating Fields (TTFields) therapy is the newest treatment modality for glioblastoma. Here, we describe the proper application of TTFields-transducer arrays on patients and discuss theory and aspects of treatment.

Difficulty
advanced
Total time
~30–60 min per treatment session; ongoing therapy over months

Steps

1
Plan TTFields treatment using tumor imaging

Review patient imaging and anatomical landmarks to determine optimal transducer array positioning over the glioblastoma target site.

▶ 01:40
2
Apply transducer arrays on patient scalp

Position and adhere TTFields transducer arrays on the patient's head according to treatment plan, ensuring proper skin contact and alignment.

▶ 03:14
3
Assemble and connect TTFields device system

Connect transducer arrays to the TTFields generator unit and verify proper system assembly before initiating treatment delivery.

▶ 04:15
4
Exchange transducer arrays during therapy

Remove and replace transducer arrays as needed during ongoing treatment to maintain optimal field delivery and skin integrity.

▶ 05:36
5
Verify transducer placement and treatment initiation

Confirm final array positioning matches treatment plan and activate TTFields device to begin tumor-treating field delivery to patient.

▶ 05:57
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